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Effect of rosuvastatin on low-density lipoprotein cholesterol in patients with hypercholesterolemia
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Internal Medicine . Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
AstraZeneca, Alderley Park, Cheshire, United Kingdom.
AstraZeneca, Alderley Park, Cheshire, United Kingdom.
AstraZeneca, Alderley Park, Cheshire, United Kingdom.
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2001 (English)In: American Journal of Cardiology, ISSN 0002-9149, Vol. 88, no 5, 504-508 p.Article in journal (Refereed) Published
Abstract [en]

Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein (LDL) cholesterol-lowering activity. We conducted 2 dose-ranging studies. In the first study, after a 6-week dietary run-in, 142 moderately hypercholesterolemic patients were randomized equally to receive double-blind placebo or rosuvastatin 1, 2.5, 5, 10, 20, or 40 mg or open-label atorvastatin 10 or 80 mg once daily for 6 weeks, in the second study, conducted to extend the rosuvastatin dose range, 64 patients were randomized to double-blind, once-daily placebo or rosuvastatin 40 or 80 mg (1:1:2 ratio) for 6 weeks. Data from both studies were combined for analysis of lipid effects. No statistical comparison of atorvastatin arms with placebo or rosuvastatin was performed. Rosuvastatin was associated with highly significant dose-dependent reductions in LDL cholesterol compared with placebo (p <0.001), decreases ranged from 34% (1 mg) to 65% (80 mg). Linear regression analysis indicated an additional 4.5% LDL cholesterol reduction for each doubling of the rosuvastatin dose. Across the dose range, approximately 90% of LDL cholesterol reduction occurred within the first 2 weeks of treatment. Significant, dose-dependent reductions in total cholesterol and apolipoprotein B with rosuvastatin were also observed (p <0.001). High-density lipoprotein cholesterol increases and triglyceride reductions were consistently observed and statistically significant at some dose levels. All lipid ratios were significantly reduced at all rosuvastatin dose levels (p <0.001). Adverse events were similar across placebo and active treatments. No significant increases in alanine aminotransferase or creatine kinase were seen in any patient. Over 6 weeks, rosuvastatin produced large, rapid, dose-dependent LDL cholesterol reductions and was well tolerated in hypercholesterolemic patients. © 2001 by Excerpta Medica, Inc.

Place, publisher, year, edition, pages
2001. Vol. 88, no 5, 504-508 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47276DOI: 10.1016/S0002-9149(01)01727-1OAI: diva2:268172
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

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Olsson, Anders
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Faculty of Health SciencesInternal Medicine Department of Endocrinology and Gastroenterology UHL
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