liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Hypoallergenicity of an extensively hydrolyzed whey formula
Department of Paediatrics, University La Sapienza, Rome, Italy.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics .
Numico Research, Wageningen, Netherlands.
Show others and affiliations
2001 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, Vol. 12, no 2, 83-86 p.Article in journal (Refereed) Published
Abstract [en]

Several different protein hydrolysate-based infant formulas have been promoted as hypoallergenic and considered suitable for the dietary management of cow's milk allergy (CMA). Accepting that none of the hydrolysate-based products is completely safe, the American Academy of Pediatrics (AAP) recommends that these formulas should be tested in a double-blind placebo-controlled setting and tolerated by at least 90% of children with proven CMA. In principle, this recommendation is also endorsed by the European Society of Paediatric Gastroenterology and Nutrition (ESPGAN) and the European Society of Paediatric Allergy and Clinical Immunology (ESPACI). In this two-center study, 32 children with proven CMA were tested with the extensive hydrolysate whey formula Nutrilon Pepti, for comparison with Profylac (extensive) and Nan HA (partial) whey hydrolysate products. Skin-prick tests (SPTs) were, respectively, positive to the three hydrolysate formulas in 19%, 15%, and 32% of children. After oral challenge it was concluded that 97% (95% CI: 85-100%) of the children tolerated Nutrilon Pepti, 94% (95% CI: 75-100%) tolerated Profylac, and 64% (95% CI: 37-81%) tolerated Nan HA. This study demonstrates that the extensive hydrolysates Nutrilon Pepti and Profylac are well tolerated in a population of children with proven CMA and that both products can be considered safe for their intended use. This study confirms that a very small number of children react even to extensively hydrolyzed formulas. SPT prior to oral exposure to the hydrolysate-based formulas can indicate whether a child is at risk of showing reactions to the product. Introduction of new products to these children should be carried out under a doctor's supervision. However, the majority of the SPT-positive children did tolerate the two extensively hydrolyzed whey-based formulas tested.

Place, publisher, year, edition, pages
2001. Vol. 12, no 2, 83-86 p.
Keyword [en]
Allergenicity, Cow's milk allergy, Cow's milk protein hydrolysate formulas, Pediatric
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47409DOI: 10.1034/j.1399-3038.2001.012002083.xOAI: diva2:268305
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Oldaeus, Göran
By organisation
Faculty of Health SciencesPediatrics
In the same journal
Pediatric Allergy and Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 46 hits
ReferencesLink to record
Permanent link

Direct link