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Stimulation of tendon repair: Mechanical loading, GDFs and platelets. a mini-review
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2007 (English)In: International Orthopaedics, ISSN 0341-2695, Vol. 31, no 6, 783-789 p.Article, review/survey (Refereed) Published
Abstract [en]

The repair of subcutaneous tendon ruptures can be stimulated by a single application of one of several growth factors [e.g. platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, insulin-like growth factor (IGF)-1, vascular endothelial growth factor (VEGF), bone morphogenetic proteins (BMPs) like growth differentiation factor (GDF)-5, -6, -7] or by a thrombocyte concentrate (PRP). The response to these measures is dependent on the mechanical microenvironment, which is crucial for repair. So far, almost all research has been limited to rodent models, mostly using the rat Achilles tendon. Ruptured human Achilles tendons appear to be mechanically loaded in spite of immobilisation. This suggests that the mechanical microenvironment might be favourable for the clinical use of growth factors or platelets for this indication. New methods to quantitate human Achilles tendon repair have been developed. © 2007 Springer-Verlag.

Place, publisher, year, edition, pages
2007. Vol. 31, no 6, 783-789 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47466DOI: 10.1007/s00264-007-0398-6OAI: diva2:268362
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports Medicine Department of Orthopaedics Linköping
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