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ECG-triggering of the laser Doppler signal - An approach for perfusion imaging on the beating calf heart
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
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2001 (English)In: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, Vol. 4254, 49-57 p.Conference paper (Other academic)
Abstract [en]

Laser Doppler perfusion imaging (LDPI) has successfully been used to map the myocardial perfusion on patients undergoing coronary bypass surgery on the arrested heart. The need for intra-operative evaluation of graft function is obvious in routine surgery but even more imperative when adapting new surgical techniques where the procedure is performed on the beating heart. When using LDPI on the beating heart, artifacts originating from the movement of the heart are superimposed on the Doppler signal. We have investigated a method to reduce these artifacts by controlling the sampling sequence with ECG-triggering. The method has been assessed in an animal model on the beating calf heart. After sternotomy, an area covering 1 cm2 was imaged at the anterior wall of the left ventricle. In this area, six perfusion images were captured each of them recorded at fixed, but different time intervals in the cardiac cycle. In addition continuous measurements at one spot was done during 1-2 minutes. The signal recorded during pumping action was high compared to measurements performed in the same muscle area during infusion of blood with a syringe pump. Repeated measurements captured at a fixed delay time from the R-peak in the same areas at the same heart frequency showed reproducibility. ECG-triggering of the laser Doppler signal is the first step in our attempts to adapt LDPI to enabling assessment of myocardial perfusion on the beating heart. Further technical achievements and in-vivo investigations are, however, needed and will be performed by our research team in future studies.

Place, publisher, year, edition, pages
2001. Vol. 4254, 49-57 p.
Keyword [en]
Beating heart, Calf model, Laser Doppler perfusion imaging, Myocardial blood flow
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-47487DOI: 10.1117/12.427946OAI: diva2:268383
Available from: 2009-10-11 Created: 2009-10-11

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Wårdell, Karin
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The Institute of TechnologyBiomedical Instrumentation
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