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Optical changes as a marker for lesion size estimation during radio frequency ablation: a model study
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
2001 (English)In: SPIE Proceedings | Volume 4254 | Guidance, Surgical-Assist and Treatment Systems / [ed] Warren S. Grundfest; David A. Benaron; Tuan Vo-Dinh, 2001, Vol. 4254, 164-171 p.Conference paper (Other academic)
Abstract [en]

Stereotactic radiofrequency (RF)-lesioning in the central part of the brain is performed on patients that, for instance, have severe movement or psychiatric disorders. The size of the generated lesion can to some extent be controlled by RF-generator settings such as temperature and time as well as the electrode configuration. Today, MR- imaging and CT are the essential diagnostic methods to confirm the lesion size in vivo. The aim of this study was to investigate whether it is possible to use changes in the reflected light intensity and laser Doppler flowmetry as a marker for size estimation during RF-lesioning.

Place, publisher, year, edition, pages
2001. Vol. 4254, 164-171 p.
Keyword [en]
Brain electrodes, Laser doppler flowmetry, Reflection spectroscopy, RF-lesioning
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-47497DOI: 10.1117/12.427930OAI: diva2:268393
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, San Jose, CA, January 20, 2001
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2013-02-26
In thesis
1. Characterisation and modelling of radio-frequency lesioning in functional neurosurgery
Open this publication in new window or tab >>Characterisation and modelling of radio-frequency lesioning in functional neurosurgery
2001 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis focuses on the characterisation and modelling of the radio frequency (RF) lesioning with emphasis on size estimation in functional neurosurgery. A computer-assisted video system has been set up for standardised test and documentation of protein clots generated by RF-lesioning electrodes in an albumin solution. A standardised test is essential in comparing assessed results of the size and shape of protein clots generated using different parameters. This is beneficial to both the manufacturer oflesioning electrodes as well as the surgeon.

In an animal study, performed analogously to thalamotomy in man, the correlation in size between in vitro protein clots and in vivo lesions has been investigated. The result shows a high correlation between protein clots and lesions observed on MR images; and lesions observed on MR images and corresponding coagulated tissue in histological sectionings. This actualises the value of presurgical electrode tests to validate the electrode function and lesion size in vitro.

A finite element model has been set-up in order to facilitate studies of the growth and the temperature distribution during the lesioning process. Of the utmost importance is the finding of a difference in temperature between maximum temperature, located outside the electrode, compared to the intra-electrode (thermocouple) temperature.

A method for real time monitoring of lesion growth and estimation of lesion size utilising static and/or Doppler broadened laser light is proposed. Implemented in a surgical-assist system, this could give valuable guidance to the surgeon as to whether the desired lesion size is obtained or not and keep the destruction precise, but to a minimum.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2001. 70 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 693
National Category
Medical and Health Sciences
urn:nbn:se:liu:diva-29440 (URN)14786 (Local ID)91-7373-033-5 (ISBN)14786 (Archive number)14786 (OAI)
Public defence
2001-06-01, Elsa Brändströmssalen, Universitetssjukhuset, Linköping, 09:15 (Swedish)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-02-26

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