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Measurement of solutes in dialysate using UV absorption
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
2001 (English)In: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, E-ISSN 1996-756X, Vol. 4263, 40-47 p.Conference paper, Published paper (Other academic)
Abstract [en]

The aim of this work was to describe a new method for optical monitoring of solutes in a spent dialysate. The method utilizes UV light absorption employing a commercially available spectrophotometer. Measurements were performed both on collected dialysate samples and on-line. The concentration of several removed solutes and electrolytes in the serum and in the dialysate was determined simultaneously using standard laboratory techniques. During on-line monitoring the spectrophotometer was connected to the fluid outlet of the dialysis machine. On-line measurements during a single hemodialysis session demonstrated a possibility to monitor deviations in the dialysator performance (e.g. dialysator in bypass). The experimental results indicated a good correlation between UV absorption and several removed solutes (urea, creatinine) in the spent dialysate. The correlation coefficient for urea and creatinine concentrations in the dialysate was very high for every individual treatment. The UV absorbance correlates well to the concentrations of several solutes thought to be uremic toxins. The results indicate that the technique can be used as a continuous, on-line method for monitoring deviations in the dialysator performance and may estimate the removal of the overall toxins. In the future, the new method will be used to evaluate parameters describing delivery of the prescribed treatment dose such as KT/V and Urea Reduction Rate (URR).

Place, publisher, year, edition, pages
2001. Vol. 4263, 40-47 p.
Keyword [en]
Dialysate, Dialysate monitor, Dialysis adequacy, Dialysis efficiency, Hemodialysis, Optical dialysate monitor, Solute removal, UV absorption
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-47500DOI: 10.1117/12.429345OAI: oai:DiVA.org:liu-47500DiVA: diva2:268396
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

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Fridolin, IvoLindberg, Lars-Göran

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