liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Bolus ornithine and arginine-ketoglutarate supplementation in distal intestine after 65% resection in rats
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology .
2000 (English)In: Nutrition Research, ISSN 0271-5317, Vol. 20, no 12, 1807-1816 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Enteral feeding has been reported to increase intestinal mucosa proliferation after resection. Dietary components influence the intestinal adaptive response. The purpose of this study was to evaluate the effect of ornithine- (OKG) or arginine-ketoglutarate (AKG) bolus supplementation on intestinal postresectional adaptation in the rat. Methods: Male Wistar rats underwent 65% small-bowel resection and received either OKG 3 g/kg/day, isonitrogenous AKG or saline by gavage once daily. The animals had free access to rat chow. Sampling was done 10 days after resection. Fed animals without surgery or specific treatment served as controls. Results: Mucosal wet weight, DNA, RNA, protein content and sucrose activity of the mucosa, as well as villus height were significantly increased in all resected animals compared to controls. No significant differences in body weight or intestinal adaptation could be found between the three dietary groups. Conclusion: Postoperative enteral bolus feeding supplemented with OKG or AKG did not significantly enhance the adaptation of the remnant small bowel 10 days after massive intestinal resection when rats had free access to rat chow. © 2000 Elsevier Science Inc.

Place, publisher, year, edition, pages
2000. Vol. 20, no 12, 1807-1816 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47527DOI: 10.1016/S0271-5317(00)00267-0OAI: diva2:268423
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-14

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Larsson, Jenny
By organisation
Faculty of Health SciencesExperimental Pathology
In the same journal
Nutrition Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link