liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Involvement of the MKK6-p38? cascade in ?-radiation-induced cell cycle arrest
Department of Immunology, Burnham Institute, San Diego, CA 92037, United States.
Department of Molecular Biology, Burnham Institute, San Diego, CA 92037, United States.
Department of Immunology, Burnham Institute, San Diego, CA 92037, United States, Department of Pathology, Linkoping University, S-581 85 Linkoping, Sweden.
Scripps Research Institute, Prog. Oncogenes Tum. Suppressor G., Burnham Institute, San Diego, CA 92037, United States.
Show others and affiliations
2000 (English)In: Molecular and Cellular Biology, ISSN 0270-7306, E-ISSN 1098-5549, Vol. 20, no 13, 4543-4552 p.Article in journal (Refereed) Published
Abstract [en]

The p38 group of kinases belongs to the mitogen-activated protein (MAP) kinase superfamily with structural and functional characteristics distinguishable from those of the ERK, JNK (SAPK), and BMK (ERK5) kinases. Although there is a high degree of similarity among members of the p38 group in terms of structure and activation, each member appears to have a unique function. Here we show that activation of p38-? (also known as ERK6 or SAPK3), but not the other p38 isoforms, is required for ?-irradiation- induced G2 arrest. Activation of the MKK6-p38? cascade is sufficient to induce G2 arrest in cells, and expression of dominant negative alleles of MKK6 or p38? allows cells to escape the DNA damage-induce G2 delay. Activation of p38? is dependent on ATM and leads to activation of Cds1 (also known as Chk2). These data suggest a model in which activation of ATM by ? irradiation leads to the activation of MKK6, p38?, and Cds1 and that activation of both MKK6 and p38? is essential for the proper regulation of the G2 checkpoint in mammalian cells.

Place, publisher, year, edition, pages
2000. Vol. 20, no 13, 4543-4552 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-47626DOI: 10.1128/MCB.20.13.4543-4552.2000OAI: oai:DiVA.org:liu-47626DiVA: diva2:268522
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13

Open Access in DiVA

No full text

Other links

Publisher's full text
In the same journal
Molecular and Cellular Biology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf