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Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Rehabilitation Medicine . Östergötlands Läns Landsting, Centre for Medicine, Pain and Rehabilitation Centre.
2003 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, Vol. 35, 89-94 p.Article in journal (Refereed) Published
Abstract [en]

According to the classification criteria proposed by the American College of Rheumatology, fibromyalgia is a long-standing multifocal pain condition combined with generalised allodynia/hyperalgesia. It is the generalised allodynia/hyperalgesia that distinguishes fibromyalgia from other conditions with chronic musculoskeletal pain. Central sensitisation of nociceptive neurons in the dorsal horn due to activation of N-methyl-D-aspartic acid receptors and disinhibition of pain due to deficient function of the descending inhibitory system are probable pathogenic factors for allodynia/hyperalgesia. Furthermore, chronic pain is a chronic emotional and physical stressor. Chronic stress and chronic sleep disturbance are not specific for fibromyalgia but could be the causes of symptoms like fatigue, cognitive difficulties and other stress-related symptoms. They may also cause neuroendocrinological and immunological aberrations.

Place, publisher, year, edition, pages
2003. Vol. 35, 89-94 p.
Keyword [en]
fibromyalgia, muscle pain, allodynia, hyperalgesia
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47786DOI: 10.1080/16501960310010215OAI: diva2:268682
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

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Henriksson, Karl-Gösta
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