Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms
2003 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, Vol. 35, 89-94 p.Article in journal (Refereed) Published
According to the classification criteria proposed by the American College of Rheumatology, fibromyalgia is a long-standing multifocal pain condition combined with generalised allodynia/hyperalgesia. It is the generalised allodynia/hyperalgesia that distinguishes fibromyalgia from other conditions with chronic musculoskeletal pain. Central sensitisation of nociceptive neurons in the dorsal horn due to activation of N-methyl-D-aspartic acid receptors and disinhibition of pain due to deficient function of the descending inhibitory system are probable pathogenic factors for allodynia/hyperalgesia. Furthermore, chronic pain is a chronic emotional and physical stressor. Chronic stress and chronic sleep disturbance are not specific for fibromyalgia but could be the causes of symptoms like fatigue, cognitive difficulties and other stress-related symptoms. They may also cause neuroendocrinological and immunological aberrations.
Place, publisher, year, edition, pages
2003. Vol. 35, 89-94 p.
fibromyalgia, muscle pain, allodynia, hyperalgesia
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-47786DOI: 10.1080/16501960310010215OAI: oai:DiVA.org:liu-47786DiVA: diva2:268682