liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans
Show others and affiliations
2003 (English)In: Journal of Medical Virology, ISSN 0146-6615, Vol. 69, no 3, 426-440 p.Article in journal (Refereed) Published
Abstract [en]

Molecular mimicry is one of the mechanisms by which enterovirus infections have been postulated to have a role in the pathogenesis of type 1 diabetes. Immunogenic epitopes in enterovirus capsid protein VP1 and procapsid protein VP0 have sequence similarities with diabetes-associated epitopes in tyrosine phosphatase IA-2/IAR and heat shock protein 60. In the present study, documented enterovirus infection was shown to induce humoral responses, that in 7% and 1% of patients cross-reacted with the known diabetes-associated epitopes in tyrosine phosphatase IAR and heat shock protein 60, respectively. In contrast, none of the children vaccinated against poliomyelitis had antibodies to the diabetes-associated epitope of tyrosine phosphatases IA-2/IAR. The antibody response studied in serum samples from six patients with coxsackievirus A9 infection was mainly targeted to capsid protein VP1. Coxsackievirus A9 infection induced antibodies cross-reacted with one epitope in heat shock protein 60, but not with epitopes derived from other autoantigens. Most diabetic children had high levels of antibodies to both coxsackievirus and poliovirus derived VP1 peptides but the pattern of reactivity did not differ from that seen in healthy children. The reactivity of linear epitopes derived from autoantigens was low in general and associated with the presence of multiple autoantibodies in the patients. Some linear auto-epitopes derived from tyrosine phosphatase IA-2, glutamic acid decarboxylase 65, preproinsulin, and heat shock protein 60 were recognized by sera from diabetic patients, but not by sera from healthy children. In conclusion, enteroviruses may induce immune responses that react with islet cell autoantigens, which is a concern when a putative inactivated enterovirus vaccine is considered.

Place, publisher, year, edition, pages
2003. Vol. 69, no 3, 426-440 p.
Keyword [en]
enterovirus, coxsackievirus, enterovirus infection, poliovirus vaccination, insulin-dependent diabetes mellitus, beta-cell autoantigens, cross-reactive epitopes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47820DOI: 10.1002/jmv.10306OAI: diva2:268716
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Vaarala, Outi
By organisation
Faculty of Health SciencesPediatrics
In the same journal
Journal of Medical Virology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 8 hits
ReferencesLink to record
Permanent link

Direct link