liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Perioperative gastric emptying is not a predictor of early postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care.
Show others and affiliations
2002 (English)In: Anesthesia and Analgesia, ISSN 0003-2999, Vol. 95, no 2, 476-479 p.Article in journal (Refereed) Published
Abstract [en]

It is not known whether patients with postoperative nausea and vomiting (PONV) have delayed gastric emptying compared with patients without PONV. We compared the perioperative rate of gastric emptying in patients experiencing PONV with the rate in those without PONV immediately after laparoscopic cholecystectomy. Gastric emptying was studied by the acetaminophen method. Acetaminophen is not absorbed from the stomach but is rapidly absorbed from the small intestine, and the rate of gastric emptying therefore determines the rate of absorption of acetaminophen administered into the stomach. Forty patients (ASA physical status I and II) were included in the study. After the induction of anesthesia, a gastric tube was positioned in the stomach and 1.5 g of acetaminophen dissolved in 200 mL of water was administered. Venous blood samples for the determination of serum acetaminophen concentrations were taken before and at 15-min intervals during a period of 180 min after the administration of acetaminophen. Twenty-six patients experienced nausea during the first 4 h postoperatively. The other 14 patients had no nausea. There were no statistically significant differences in the maximal acetaminophen concentration, the time taken to reach the maximal concentration, or the area under the serum acetaminophen concentration time curves from 0 to 60, 0-120, and 0-180 min between the groups of patients with or without PONV. We did not find any relationship between postoperative gastric emptying and PONV, and therefore gastric emptying is not a predictor of PONV.

Place, publisher, year, edition, pages
2002. Vol. 95, no 2, 476-479 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47873DOI: 10.1213/01.ANE.0000020386.18379.19OAI: diva2:268769
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Wattwil, Magnus
By organisation
Faculty of Health SciencesDepartment of Medicine and Care
In the same journal
Anesthesia and Analgesia
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link