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A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families
Karolinska Inst, Karolinska Univ Hosp, Dept Oncol, S-11883 Stockholm, Sweden .
Karolinska Univ Hosp, Dept Mol Med & Surg, CMM, Stockholm, Sweden .
Umea Univ Hosp, Ctr Oncol, S-90185 Umea, Sweden .
Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden .
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2007 (English)In: HEREDITY CANCER IN CLINICAL PRACTICE, ISSN 1731-2302, Vol. 5, no 1, 17-24 p.Article in journal (Refereed) Published
Abstract [en]

Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000. Four thousand families from counselling clinics in Sweden were eligible for study. Families with breast cancer only were excluded, as were families with mutations in genes already known to be associated with malignant diseases. We identified 803 families with two or more cases of breast cancer and at least one other type of cancer. The observed proportion of different types of non-breast cancer was compared with the percentage distribution of non-breast cancer tumours in Sweden in 1958 and 1999. We found tumours in the colon, ovary, endometrium, pancreas and liver, as well as leukaemia in a significantly larger proportion of the study population than in the general population in both years. These tumours were also seen among families where several members had one additional tumour, suggesting that malignancies at these sites, in combination with breast tumours, could constitute genetic syndromes. Endometrial carcinoma has not previously been described in the context of breast cancer syndromes and the excess of malignancies at this site could not be explained by secondary tumours. Thus, we suggest that endometrial carcinoma and breast cancer constitute a new breast cancer syndrome. Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup.

Place, publisher, year, edition, pages
2007. Vol. 5, no 1, 17-24 p.
Keyword [en]
breast cancer, endometrial cancer, family history, syndromes, genetics
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-47960OAI: diva2:268856
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Gårdman, Camilla
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Faculty of Health SciencesDepartment of Molecular and Clinical Medicine
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