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Increased Prevalence of Anti-Gliadin IgA-Antibodies with Aberrant Duodenal Histopathological Findings in Patients with IgA-Nephropathy and Related Disorders
Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, General Practice. Linköping University, Faculty of Health Sciences.
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2006 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 111, no 3, 339-352 p.Article in journal (Refereed) Published
Abstract [en]

Background: Antibodies present in coeliac disease may occur in IgA-nephropathy. This raises the question of food intolerance in the disease. Evidence for a true correlation between the two disorders has however been scarce.

Design: Sera from 89 patients with IgA-nephropathy and 13 other patients with IgA deposits in the glomeruli of kidney biopsies were analysed for IgA-antibodies to gliadin, endomysium and tissue transglutaminase (92/102 patients).

Results: Eleven out of 89 (12.4%) of the patients with IgA-nephropathy and five of the 13 others (38%) had elevated titres of IgA-antibodies to gliadin but, in all cases but one, normal IgA-antibodies to endomysium. Patients with IgA-nephropathy and elevated IgA-antibodies to gliadin had elevated total serum IgA more frequently than patients who had not (p<0.01). Two patients with IgA-nephropathy and one with Hennoch Schönlein's purpura had elevated IgA-antibodies to tissue transglutaminase.

Small bowel biopsy in 7 out of 11 IgA-antibodies to gliadin positive patients with IgA-nephropathy was pathologic in three cases (two with Marsh I). One patient with chronic glomerulnephritis also had Marsh I.

Conclusions: We found no increased frequency of verified coeliac disease in 89 patients with IgA-nephropathy. Two patients with IgA-nephropathy and one patient with chronic glomerulonephritis with IgA deposits in the kidney biopsy had a Marsh I histopathology. The findings suggest a possible link of celiac disease to IgA-nephropathy and a role for antibodies to food antigens in this disorder.

Place, publisher, year, edition, pages
2006. Vol. 111, no 3, 339-352 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48041DOI: 10.3109/2000-1967-060PubMedID: 17578801OAI: oai:DiVA.org:liu-48041DiVA: diva2:268937
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-09-04Bibliographically approved

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Almroth, GabrielGrodzinsky, EwaMidhagen, GunnarOlcén, Per

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