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Analysis of skeletal microstructure with clinical multislice CT
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Department of Radiology, Karolinska University Hospital Huddinge, Sweden .
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medicine and Care. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-7750-1917
2006 (English)In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006: 9th International Conference, Copenhagen, Denmark, October 1-6, 2006. Proceedings, Part II / [ed] Rasmus Larsen, Mads Nielsen, Jon Sporring, Springer Berlin/Heidelberg, 2006, Vol. 4191, 880-887 p.Conference paper, Published paper (Refereed)
Abstract [en]

In view of the great effects of osteoporosis on public health, it would be of great value to be able to measure the three-dimensional structure of trabecular bone in vivo as a means to diagnose and quantify the disease. The aim of this work was to implement a method for quantitative characterisation of trabecular bone structure using clinical CT. Several previously described parameters have been calculated from volumes acquired with a 64-slice clinical scanner. Using automated region growing, distance transforms and three-dimensional thinning, measures describing the number, thickness and spacing of bone trabeculae was obtained. Fifteen bone biopsies were analysed. The results were evaluated using micro-CT as reference. For most parameters studied, the absolute values did not agree well with the reference method, but several parameters were closely correlated with the reference method. The shortcomings appear to be due to the low resolution and high noise level. However, the high correlation found between clinical CT and micro-CT measurements suggest that it might be possible to monitor changes in the trabecular structure in vivo.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2006. Vol. 4191, 880-887 p.
Series
Lecture Notes in Computer Science, ISSN 0302-9743 (print), 1611-3349 (online) ; 4191
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:liu:diva-48052DOI: 10.1007/11866763_108ISI: 000241556700108ISBN: 978-3-540-44727-6 (print)ISBN: 978-3-540-44728-3 (print)ISBN: 3-540-44727-X (print)OAI: oai:DiVA.org:liu-48052DiVA: diva2:268948
Conference
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006, 9th International Conference, Copenhagen, Denmark, October 1-6, 2006
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2015-08-19Bibliographically approved

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Petersson, JoelSmedby, Örjan

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Center for Medical Image Science and Visualization (CMIV)Department of Science and TechnologyThe Institute of TechnologyDepartment of Medicine and CareFaculty of Health SciencesDepartment of Radiology in Linköping
Medical Image Processing

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