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Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months
Department of Hematology, Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden, Department of Medicine, McMaster University, Hamilton, Ont., Canada, Thrombosis Service, McMaster Clinic, HHS - General Hospital, Hamilton, Ont. L8L 2X2, Canada.
Department of Emergency Medicine, Karolinska University Hospital, Karolinska, Sweden.
Holmström, M., Department of Hematology, Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden, Department of Medicine, Huddinge Hospital, Huddinge, Sweden.
Läfars, G., Södersjukhuset, Sweden.
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2006 (English)In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 4, no 4, 734-742 p.Article in journal (Refereed) Published
Abstract [en]

Background: The influence of the duration of anticoagulant therapy after venous thromboembolism (VTE) on the long-term morbidity and mortality is unclear. Aim: To investigate the long-term sequelae of VTE in patients randomized to different duration of secondary prophylaxis. Methods: In a multicenter trial comparing secondary prophylaxis with vitamin K antagonists for 6 weeks or 6 months, we extended the originally planned 2 years follow-up to 10 years. The patients had annual visits and at the last visit clinical assessment of the post-thrombotic syndrome (PTS) was performed. Recurrent thromboembolism was adjudicated by a radiologist, blinded to treatment allocation. Causes of death were obtained from the Swedish Death Registry. Results: Of the 897 patients randomized, 545 could be evaluated at the 10 years follow-up. The probability of developing severe PTS was 6% and any sign of PTS was seen in 56.3% of the evaluated patients. In multivariate analysis, old age and signs of impaired circulation at discharge from the hospital were independent risk factors at baseline for development of PTS after 10 years. Recurrent thromboembolism occurred in 29.1% of the patients with a higher rate among males, older patients, those with permanent gering risk factor - especially with venous insufficiency at baseline - signs of impaired venous circulation at discharge, proximal deep vein thrombosis, or pulmonary embolism. Death occurred in 28.5%, which was a higher mortality than expected with a standardized incidence ratio (SIR) of 1.43 (95% CI 1.28-1.58), mainly because of a higher mortality than expected from cancer (SIR 1.83, 95% CI 1.44-2.23) or from myocardial infarction or stroke (SIR 1.28, 95% CI 1.00-1.56).The duration of anticoagulation did not have a statistically significant effect on any of the long-term outcomes. Conclusion: The morbidity and mortality during 10 years after the first episode of VTE is high and not reduced by extension of secondary prophylaxis from 6 weeks to 6 months. A strategy to reduce recurrence of VTE as well as mortality from arterial disease is needed. © 2006 International Society on Thrombosis and Haemostasis.

Place, publisher, year, edition, pages
2006. Vol. 4, no 4, 734-742 p.
Keyword [en]
Death, Deep vein thrombosis, Myocardial infarction, Post-thrombotic syndrome, Pulmonary embolism, Recurrence, Stroke, Warfarin
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-48055DOI: 10.1111/j.1538-7836.2006.01795.xOAI: diva2:268951
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-06

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Östergötlands Läns Landsting
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