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Oxidative stress and Alzheimer disease - The autophagy connection?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Geriatric .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Geriatric . Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Geriatric Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Geriatric .
2006 (English)In: AUTOPHAGY, ISSN 1554-8627, Vol. 2, no 2, 143-145 p.Article in journal (Refereed) Published
Abstract [en]

Intraneuronal accumulation of amyloid beta-protein (A beta) is believed to be responsible for degeneration and apoptosis of neurons and consequent senile plaque formation in Alzheimer disease (AD), the main cause of senile dementia. Oxidative stress, an early determinant of AD, has been recently found to induce intralysosomal A beta accumulation in cultured differentiated neuroblastoma cells through activation of macroautophogy. Because A beta is known to destabilize lysosomal membranes, potentially resulting in apoptotic cell death, this finding suggests the involvement of oxidative stress-induced macroautophagy in the pathogenesis of AD.

Place, publisher, year, edition, pages
2006. Vol. 2, no 2, 143-145 p.
Keyword [en]
Alzheimer disease, amyloid beta-protein, autophagy, lysosomes, oxidative stress
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48087OAI: oai:DiVA.org:liu-48087DiVA: diva2:268983
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Zheng, LinMarcusson, JanTerman, Alexei

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