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Stress-related changes in oesophageal permeability: Filling the gaps of GORD?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
2007 (English)In: Gut, ISSN 0017-5749, Vol. 56, no 9, 1177-1180 p.Article, review/survey (Refereed) Published
Abstract [en]

Albeit remaining a controversial issue, it has become increasingly recognised that psychological stress has a major impact on gut mucosal function and affects the course of gastrointestinal disorders. Research during the last decade has shown that stress causes barrier dysfunction of the gastrointestinal mucosa by mechanisms that mainly involve neuropeptides and mast cells. Moreover, accumulating evidence implicates increased permeability as a pathogenic factor in gastroesophageal reflux disease (GORD). Recent data demonstrating that psychological stress may induce a permeability defect in stratified epithelia, including the oesophagus, shed new light on the pathophysiological events leading to heartburn and GORD.

Place, publisher, year, edition, pages
2007. Vol. 56, no 9, 1177-1180 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-48166DOI: 10.1136/gut.2007.120691OAI: diva2:269062
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Söderholm, Johan D
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Faculty of Health SciencesSurgery Department of Surgery in Östergötland
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