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Continuous weak-affinity immunosensing
Kalmar.
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering.
Kalmar.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biotechnology.
2000 (English)In: Trends in Biotechnology, ISSN 0167-7799, E-ISSN 1879-3096, Vol. 18, no 2, 49-52 p.Article in journal (Refereed) Published
Abstract [en]

A multitude of weak biological interactions, either working alone or in concert, occur frequently throughout biological systems. We have used this natural feature of readily reversible interactions as the basis for continuous immunosensing. In a model system, a set of weak monoclonal antibodies directed towards a carbohydrate epitope was studied with the aid of surface plasmon resonance. Because the system requires no regeneration, it can be used as a truly on-line immunosensing device. This principle should have wide application in all areas where there is a need for the continuous evaluation of a molecule.

Place, publisher, year, edition, pages
2000. Vol. 18, no 2, 49-52 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-48375DOI: 10.1016/S0167-7799(99)01411-0OAI: oai:DiVA.org:liu-48375DiVA: diva2:269271
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Jungar, ChristinaMandenius, Carl-Fredrik

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