A Skolem sequence is a sequence a1, a2, ..., a2 n (where ai ? A = { 1, ..., n }), each ai occurs exactly twice in the sequence and the two occurrences are exactly ai positions apart. A set A that can be used to construct Skolem sequences is called a Skolem set. The existence question of deciding which sets of the form A = { 1, ..., n } are Skolem sets was solved by Skolem [On certain distributions of integers in pairs with given differences, Math. Scand. 5 (1957) 57-68] in 1957. Many generalizations of Skolem sequences have been studied. In this paper we prove that the existence question for generalized multi-Skolem sequences is NP-complete. This can be seen as an upper bound on how far the generalizations of Skolem sequences can be taken while still hoping to resolve the existence question. © 2007 Elsevier B.V. All rights reserved.