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Intracerebral microvascular measurements during deep brain stimulation implantation using laser doppler perfusion monitoring
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
Department of Neurosurgery, University Hospital, Umeå, Sweden.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. (MINT)
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
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2007 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 85, no 6, 279-286 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to investigate if laser Doppler perfusion monitoring (LDPM) can be used in order to differentiate between gray and white matter and to what extent microvascular perfusion can be recorded in the deep brain structures during stereotactic neurosurgery. An optical probe constructed to fit in the Leksell® Stereotactic System was used for measurements along the trajectory and in the targets (globus pallidus internus, subthalamic nucleus, zona incerta, thalamus) during the implantation of deep brain stimulation leads (n = 22). The total backscattered light intensity (TLI) reflecting the grayness of the tissue, and the microvascular perfusion were captured at 128 sites. Heartbeat-synchronized pulsations were found at all perfusion recordings. In 6 sites the perfusion was more than 6 times higher than the closest neighbor indicating a possible small vessel structure. TLI was significantly higher (p < 0.005) and the perfusion significantly lower (p < 0.005) in positions identified as white matter in the respective MRI batch. The measurements imply that LDPM has the potential to be used as an intracerebral guidance tool.

Place, publisher, year, edition, pages
S. Karger, 2007. Vol. 85, no 6, 279-286 p.
Keyword [en]
Deep brain stimulation, Laser Doppler perfusion monitoring, Microcirculation
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:liu:diva-48444DOI: 10.1159/000107360ISI: 000249535300004PubMedID: 17709980Scopus ID: 2-s2.0-35348889232OAI: oai:DiVA.org:liu-48444DiVA: diva2:269340
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12Bibliographically approved

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Wårdell, KarinRichter, JohanAntonsson, JohanEriksson, OlaZsigmond, Peter

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Wårdell, KarinRichter, JohanAntonsson, JohanEriksson, OlaZsigmond, Peter
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Biomedical InstrumentationThe Institute of TechnologyFaculty of Health SciencesNeurosurgeryDepartment of Neurosurgery UHL
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Stereotactic and Functional Neurosurgery
Biomedical Laboratory Science/Technology

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