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Benign gastric polyps - Morphological and functional origin
Linköping University, Department of Clinical and Experimental Medicine, Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology . Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Cell Biology.
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2003 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 48, no 7, 1292-1297 p.Article in journal (Refereed) Published
Abstract [en]

The most common types of benign gastric polyps are fundic gland polyps, hyperplastic polyps, and adenomas. The aim of this study was to determine on which morphological and functional background benign gastric polyps develop. The study includes 85 consecutive patients with gastric polyps and sex and age-matched controls without polyps selected at random from a general population sample. The type of polyp was hyperplastic in 52 (61%), fundic gland in 18 (21%), adenoma in 10 (12%), carcinoid in 2 (2%), hamartoma in 2 ( 2%), and inflammatory fibroid in 1 (1%) of the cases. Routine biopsies from the gastric corpus and antrum were examined for presence of gastritis and H. pylori. Blood samples were analyzed for H. pylori antibodies, H+, K+-ATPase antibodies, gastrin, and pepsinogen I. Patients with hyperplastic polyps had increased P-gastrin concentrations and S-H+, K+-ATPase antibody titers and decreased S-pepsinogen I concentrations with a high prevalence of atrophic corpus gastritis or pangastritis. A similar pattern was observed among patients with adenomas, whereas patients with fundic gland polyps had normal serology and a lower prevalence of gastritis and H. pylori infection than controls. In conclusion, hyperplastic polyps and adenomas are generally associated with atrophic gastritis. Patients with fundic gland polyps seem to have a sounder mucosa than controls. Whereas the risk of malignant gastric neoplasia is increased in patients with hyperplastic polyps or adenomas, this does not seem to be the case in patients with fundic gland polyps.

Place, publisher, year, edition, pages
2003. Vol. 48, no 7, 1292-1297 p.
Keyword [en]
gastrin, gastritis, Helicobacter pylori, H+, K+-ATPase antibodies, morphology, pepsinogen I, polyps, stomach
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-48631OAI: oai:DiVA.org:liu-48631DiVA: diva2:269527
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Borch, KurtFranzén, LennartMårdh, Sven

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Borch, KurtFranzén, LennartMårdh, Sven
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Surgery Faculty of Health SciencesDepartment of Surgery in ÖstergötlandExperimental Pathology Department of Clinical Pathology and Clinical GeneticsCell Biology
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