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An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: A multi-center study of 381 patients
Department of Haematology, Karolinska University Hospital, Sweden, Haematology Centre, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.
Hägglund, H., Department of Haematology, Karolinska University Hospital, Sweden.
Department of Haematology, Malmö University Hospital, Sweden.
Department of Haematology, Karolinska University Hospital, Sweden.
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2008 (English)In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 93, no 11, 1734-1738 p.Article in journal (Refereed) Published
Abstract [en]

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9,22)/BCR-ABL and t(4,11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9,22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9,22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia. ©2008 Ferrata Storti Foundation.

Place, publisher, year, edition, pages
2008. Vol. 93, no 11, 1734-1738 p.
Keyword [en]
9p21, Leukemia, p14ARF, p53
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48654DOI: 10.3324/haematol.13227OAI: oai:DiVA.org:liu-48654DiVA: diva2:269550
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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