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Expression of p53, PCNA, Ki-67 and bcl-2 in relation to risk factors in oral cancer - a molecular epidemiological study
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden Umea Univ, Dept Oncol, S-90187 Umea, Sweden Umea Univ, Dept Med Biosci Pathol, S-90187 Umea, Sweden Orebro Med Ctr Hosp, Dept Oncol, S-70185 Orebro, Sweden Linkoping Univ Hosp, Dept Occupat & Environm Med, S-58185 Linkoping, Sweden.
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden Umea Univ, Dept Oncol, S-90187 Umea, Sweden Umea Univ, Dept Med Biosci Pathol, S-90187 Umea, Sweden Orebro Med Ctr Hosp, Dept Oncol, S-70185 Orebro, Sweden Linkoping Univ Hosp, Dept Occupat & Environm Med, S-58185 Linkoping, Sweden.
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden Umea Univ, Dept Oncol, S-90187 Umea, Sweden Umea Univ, Dept Med Biosci Pathol, S-90187 Umea, Sweden Orebro Med Ctr Hosp, Dept Oncol, S-70185 Orebro, Sweden Linkoping Univ Hosp, Dept Occupat & Environm Med, S-58185 Linkoping, Sweden.
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2003 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 22, no 4, 861-868 p.Article in journal (Refereed) Published
Abstract [en]

A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The TP53 gene was studied for mutations using PCR amplification of exons 5-9 and single strand conformation polymorphism (SSCP) analysis. The collected data were correlated to the exposure factors smoking, oral snuff, liquor, oral infections, dental factors, dental X-ray and iron deficiency. When compared with matched controls only oral infections, and reported HSV-infections in particular, gave statistically significant ORs (odds ratio) for all tumours (OR 8.0) as well as for the group of IHC p53 positive tumours (OR 12). No association between smoking and p53 positivity was found (OR 1.0).

Place, publisher, year, edition, pages
2003. Vol. 22, no 4, 861-868 p.
Keyword [en]
oral cancer, TP53 gene, PCNA, Ki-67, oral infection, molecular epidemiology
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Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48672OAI: oai:DiVA.org:liu-48672DiVA: diva2:269568
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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