liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Non-invasive cardiac assessment in beta-thalassaemia major
Univ Malaya, Dept Med, Kuala Lumpur, Malaysia Linkoping Univ Hosp, Dept Clin Physiol, S-58185 Linkoping, Sweden.
Univ Malaya, Dept Med, Kuala Lumpur, Malaysia Linkoping Univ Hosp, Dept Clin Physiol, S-58185 Linkoping, Sweden.
Univ Malaya, Dept Med, Kuala Lumpur, Malaysia Linkoping Univ Hosp, Dept Clin Physiol, S-58185 Linkoping, Sweden.
Univ Malaya, Dept Med, Kuala Lumpur, Malaysia Linkoping Univ Hosp, Dept Clin Physiol, S-58185 Linkoping, Sweden.
2002 (English)In: International journal of clinical practice (Esher), ISSN 1368-5031, E-ISSN 1742-1241, Vol. 56, no 5, 345-348 p.Article in journal (Refereed) Published
Abstract [en]

Iron deposition in the heart occurs in beta-thalassaemia major and contributes to cardiac dysfunction. Eighteen patients with beta-thalassaemia major were assessed clinically and had non-invasive investigations. They were young (15.5 +/- 3.6 years). Two patients had clinical heart failure. Doppler echocardiography demonstrated higher transmitral peak flow velocity in early and late diastole compared with controls (e: p<0.05, a: p<0.01). Transtricuspid peak late diastolic flow velocity was higher in patients (p<0.005). Isovolumic relaxation time was shortened (p<0.001). Pulmonary venous flow velocity was higher in diastole than systole (S: 0.51 +/- 0.11 m/s, D: 0.62 +/- 0.08 m/s). Reversal of pulmonary venous flow during atrial systole was seen in eight patients. These diastolic filling abnormalities did not significantly change with blood transfusion. Left ventricular ejection fraction was normal in patients. Two patients had cardiomegaly on chest X-ray. In beta-thalassaemia with iron overload, there is a restrictive pattern of diastolic dysfunction. This is not altered by recent blood transfusion. Left ventricular function remains relatively intact.

Place, publisher, year, edition, pages
2002. Vol. 56, no 5, 345-348 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48859OAI: oai:DiVA.org:liu-48859DiVA: diva2:269755
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

Open Access in DiVA

No full text

In the same journal
International journal of clinical practice (Esher)
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 17 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf