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Correcting for non-compliance bias in case-control studies to evaluate cancer screening programmes
Imperial Canc Res Fund, Dept Math Stat & Epidemiol, London WC2A 3PX, England Cent Hosp Falun, Falun, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Natl Taiwan Univ, Taipei 10764, Taiwan Amer Canc Soc, Atlanta, GA 30329 USA.
Imperial Canc Res Fund, Dept Math Stat & Epidemiol, London WC2A 3PX, England Cent Hosp Falun, Falun, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Natl Taiwan Univ, Taipei 10764, Taiwan Amer Canc Soc, Atlanta, GA 30329 USA.
Imperial Canc Res Fund, Dept Math Stat & Epidemiol, London WC2A 3PX, England Cent Hosp Falun, Falun, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Natl Taiwan Univ, Taipei 10764, Taiwan Amer Canc Soc, Atlanta, GA 30329 USA.
Östergötlands Läns Landsting.
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2002 (English)In: Journal of the Royal Statistic Society, Series C: Applied Statistics, ISSN 0035-9254, E-ISSN 1467-9876, Vol. 51, 235-243 p.Article in journal (Refereed) Published
Abstract [en]

In the evaluation of uncontrolled service screening programmes for cancer, the case-control design is sometimes used, in which people who die from the disease in question are compared with live controls with respect to screening histories, Such a design tends to yield estimates of relative mortality in voluntary participants compared with non-participants. This may bias results, since compliers and non-compliers may differ a priori in ways which are not related to screening but which nevertheless affect the risk of death from the disease. We present a simple method, employing external data from previously published randomized controlled trials of screening, of correction for this bias. We illustrate it by using data from a case-control study performed within the invited arm of the Malmo mammographic screening trial, a prospective study from the service screening programme in two counties in Sweden, and a matched case-control study of mammographic screening in Florence, Italy.

Place, publisher, year, edition, pages
2002. Vol. 51, 235-243 p.
Keyword [en]
cancer screening, case-control study, selection bias
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48901OAI: oai:DiVA.org:liu-48901DiVA: diva2:269797
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-08

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