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A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients
ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
Östergötlands Läns Landsting.
ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
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2002 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 82, no 1, 45-47 p.Article in journal (Refereed) Published
Abstract [en]

Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to apply the cream at least once daily for 30 days. Adverse skin reactions and changes in skin dryness were assessed by the patient and a dermatologist. Adverse skin reactions such as smarting (a sharp local superficial sensation) were felt significantly less among patients using the 20% glycerin cream compared with the urea-saline cream, because 10% of the patients judged the smarting as severe or moderate when using glycerin cream, whereas 24% did so using urea-saline cream (p

Place, publisher, year, edition, pages
2002. Vol. 82, no 1, 45-47 p.
Keyword [en]
cream, dry skin, emollients, moisturizer
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-48920OAI: oai:DiVA.org:liu-48920DiVA: diva2:269816
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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