The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) trial: a new frontier for statins?
2001 (English)In: Current controlled trials. Cardiovascular medicine (Online), ISSN 1468-6694, Vol. 2, no 3, 111-114 p.111-114 p.Article in journal, Editorial material (Other academic) Published
The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) Trial tested the hypothesis that intensive lowering of cholesterol with atorvastatin (80 mg/day) initiated 24-96 h after an acute coronary syndrome would, over 4 months, reduce the incidence of the composite endpoint of death, nonfatal infarction, resuscitated cardiac arrest, and recurrent symptomatic myocardial ischemia with new objective symptoms requiring emergency rehospitalization. This primary composite endpoint was reduced from 17.4% to 14.8% (P = 0.048) among the 3086 patients enrolled. The results of MIRACL suggest that patients with acute coronary syndromes should begin to receive this treatment before leaving hospital, irrespective of baseline levels of low-density lipoprotein-cholesterol.
Place, publisher, year, edition, pages
London, UK: BioMed Central, 2001. Vol. 2, no 3, 111-114 p.111-114 p.
atorvastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, myocardial infarction, unstable angina
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-48980DOI: 10.1186/cvm-2-3-111ISI: 000173941200003OAI: oai:DiVA.org:liu-48980DiVA: diva2:269876