p73 overexpression is a prognostic factor in patients with colorectal adenocarcinoma
2002 (English)In: Clinical Cancer Research, ISSN 1078-0432, Vol. 8, no 1, 165-170 p.Article in journal (Refereed) Published
Purpose: To examine the expression of p73 in the different stages of colorectal cancer development and the association of p73 expression with patient survival. Experimental Design: Expression of p73 protein was evaluated by immunohistochemistry in 221 primary colorectal cancer patients, including 58 patients with matched normal mucosa and metastases in the regional lymph nodes. Results: Frequency and intensity of p73 expression were markedly increased from the normal samples (19%) to primary tumors (67%) and to metastases (95%). Overexpression of p73 predicted poor outcome in the whole group of patients (P = 0.014) and the subgroups with left-sided (P = 0.002) or ras-positive tumors (P = 0.019). The prognostic significance remained in the whole group (P = 0.008) and the subgroup with left-sided tumors (P = 0.019) after adjustment for the patient's sex, age, tumor stage, growth pattern, and differentiation. The p73 expression was positively correlated with ras expression (P = 0.006). The 5-year survival rates were 37, 53, 72, and 74% for the patients with p73+/ras+, p73+/ras-, p73-/ras+, and p73-/ras- tumors, respectively (P = 0.007). Conclusion: Our data indicate that overexpression of p73 independently predicted poor prognosis in the patients with colorectal cancer.
Place, publisher, year, edition, pages
2002. Vol. 8, no 1, 165-170 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-48996OAI: oai:DiVA.org:liu-48996DiVA: diva2:269892