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Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol
Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
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2001 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 30, no 6, 328-334 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. Methods: Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4.8 weeks: maintenance: after 6 months). Results: Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problem. and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux. abdominal pain and indigestion symptoms, During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea, Conclusion: QoL in arthritis patient, on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.

Place, publisher, year, edition, pages
2001. Vol. 30, no 6, 328-334 p.
Keyword [en]
quality of life, arthritis, clinical trial, omeprazole, misoprostol, NSAIDs, gastrointestinal symptoms, heartburn
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-49018OAI: oai:DiVA.org:liu-49018DiVA: diva2:269914
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-13

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