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Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
Karolinska Hospital, Stockholm, Sweden, Karolinska Institute, Stockholm, Sweden.
Franzén, L., Länssjukhuset Sundsvall-Härnösand, Sundsvall, Sweden.
Institute of Cancer Research, Royal Marsden Hospital, Sutton, United Kingdom.
Plymouth General Hospital, Plymouth, United Kingdom.
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2007 (English)In: The Lancet Oncology, ISSN 1470-2045, E-ISSN 1474-5488, Vol. 8, no 7, 587-594 p.Article in journal (Refereed) Published
Abstract [en]

Background: The alpha-emitter radium-223 (223Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of 223Ra. Methods: Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of 223Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. Primary endpoints were change in bone-alkaline phosphatase (ALP) concentration and time to skeletal-related events (SREs). Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. All tests were done at a 5% significance level, based on intention to treat. Findings: Median relative change in bone-ALP during treatment was -65·6% (95% CI -69·5 to -57·7) and 9·3% (3·8-60·9) in the 223Ra group and placebo groups, respectively (p

Place, publisher, year, edition, pages
2007. Vol. 8, no 7, 587-594 p.
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-49310DOI: 10.1016/S1470-2045(07)70147-XOAI: diva2:270206
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-06

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Östergötlands Läns Landsting
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