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Scintigraphic study of the major salivary glands in pediatric bone marrow transplant recipients
Karolinska Inst, Dept Pediat Dent, Stockholm, Sweden Huddinge Univ Hosp, Dept Nucl Med, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Ctr Allogene Stem Cell Transplantat, S-14186 Huddinge, Sweden.
Karolinska Inst, Dept Pediat Dent, Stockholm, Sweden Huddinge Univ Hosp, Dept Nucl Med, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Ctr Allogene Stem Cell Transplantat, S-14186 Huddinge, Sweden.
Karolinska Inst, Dept Pediat Dent, Stockholm, Sweden Huddinge Univ Hosp, Dept Nucl Med, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Ctr Allogene Stem Cell Transplantat, S-14186 Huddinge, Sweden.
Karolinska Inst, Dept Pediat Dent, Stockholm, Sweden Huddinge Univ Hosp, Dept Nucl Med, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Ctr Allogene Stem Cell Transplantat, S-14186 Huddinge, Sweden.
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2000 (English)In: Bone Marrow Transplantation, ISSN 0268-3369, E-ISSN 1476-5365, Vol. 26, no 7, 775-779 p.Article in journal (Refereed) Published
Abstract [en]

Total body irradiation (TBI) at bone marrow transplantation (BMT) is shown to cause salivary gland dysfunction in children. The aim of the investigation was to study the function of major salivary glands in long-term surviving children following treatment with TBI, using salivary gland scintigraphy (SGS), Thirteen patients (seven male, six female), who had received TBI before the age of 13 years and survived more than 4 years, participated in the study. A reference group of 10 patients (nine male, one female) was examined shortly before they were to undergo BMT, The mean age was 14.1 +/- 4.1 years in the TBI-treated group and 12.8 +/- 5.9 years in the reference group, Unstimulated and stimulated whole salivary secretion rates were measured for 15 and 5 min, respectively, before SGS was performed, The percentage of stimulated secretion was 44.7 +/- 18.1% in the TBI-treated group compared to 58.4 +/- 13.0% in the reference group (P = 0.0438). Slower reaccumulation after excretion was found in the TBI-treated patients compared to the reference group (P = 0.0300). The function of the major salivary glands in long-term survivors treated with TBI at BMT before the age of 13 years was found to be diminished, as shown by the reduced trapping rate and reduced emptying capacity, compared to prior to BMT.

Place, publisher, year, edition, pages
2000. Vol. 26, no 7, 775-779 p.
Keyword [en]
children, saliva, scintigraphy, total body irradiation
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-49573OAI: oai:DiVA.org:liu-49573DiVA: diva2:270469
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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