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Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury
Apoptosis Research Group, Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Southport, QLD 9716, Australia, Molecular Therapy Group, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Widén, C., Apoptosis Research Group, Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Southport, QLD 9716, Australia.
Apoptosis Research Group, Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Southport, QLD 9716, Australia.
Apoptosis Research Group, Heart Foundation Research Centre, Griffith University, Gold Coast Campus, Southport, QLD 9716, Australia.
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2007 (English)In: Redox report, ISSN 1351-0002, E-ISSN 1743-2928, Vol. 12, no 3, 148-162 p.Article in journal (Refereed) Published
Abstract [en]

Ischemia-reperfusion (I/R) is a condition leading to serious complications due to death of cardiac myocytes. We used the cardiomyocyte-like cell line H9c2 to study the mechanism underlying cell damage. Exposure of the cells to simulated I/R lead to their apoptosis. Over-expression of Bcl-2 and Bcl-xL protected the cells from apoptosis while over-expression of Bax sensitized them to programmed cell death induction. Mitochondria-targeted coenzyme Q (mitoQ) and superoxide dismutase both inhibited accumulation of reactive oxygen species (ROS) and apoptosis induction. Notably, mtDNA-deficient cells responded to I/R by decreased ROS generation and apoptosis. Using both in situ and in vivo approaches, it was found that apoptosis occurred during reperfusion following ischemia, and recovery was enhanced when hearts from mice were supplemented with mitoQ. In conclusion, I/R results in apoptosis in cultured cardiac myocytes and heart tissue largely via generation of mitochondria-derived superoxide, with ensuing apoptosis during the reperfusion phase. © W. S. Maney & Son Ltd.

Place, publisher, year, edition, pages
2007. Vol. 12, no 3, 148-162 p.
Keyword [en]
Apoptosis, Cardiomyocytes, Ischemia/reperfusion, Mitochondria, Superoxide
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-49610DOI: 10.1179/135100007X200227OAI: oai:DiVA.org:liu-49610DiVA: diva2:270506
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Dalen, Helge

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