ECT in Parkinson's disease - dopamine transporter visualised by [I-123]-beta-CIT SPECT
2000 (English)In: Journal of neural transmission, ISSN 0300-9564, Vol. 107, no 8-9, 997-1008 p.Article in journal (Refereed) Published
Parkinson's disease (PD) is characterised by a loss of dopaminergic neurones in the basal ganglia. These neurones may be visualised by single photon emission computed tomography (SPECT) with the cocaine analogue 2 beta-carboxymethyl-3-beta-(4-iodophenyl)tropane ([(123)]beta-CIT), which labels the dopamine reuptake sites in the nerve terminals. In order to evaluate the possibility to predict the outcome of ECT a prospective study was performed with six PD patients in whom the [I-123]beta-CIT uptake was measured before and after an electroconvulsive therapy (ECT) series. The side-to-side difference in the radiotracer uptake was found to be significantly lower in striatum located contralaterally to the part of the body with the most pronounced symptomathology. No significant change in uptake of the radioligand was seen after ECT. Patients with best uptake and thus with less advanced PD improved most after ECT. The possibility to use the [I-123]beta-CIT uptake to predict the outcome of ECT treatment has to be further evaluated.
Place, publisher, year, edition, pages
2000. Vol. 107, no 8-9, 997-1008 p.
Parkinson's disease, electroconvulsive therapy, single photon emission computerized tomography (SPECT), [I-123]beta-CIT
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-49623OAI: oai:DiVA.org:liu-49623DiVA: diva2:270519