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Treatment with 2% clindamycin vaginal cream prior to first trimester surgical abortion to reduce signs of postoperative infection: A prospective, double-blinded, placebo-controlled, multicenter study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Gender and medicine .
Cent Hosp Skovde, Dept Obstet & Gynaecol, S-54185 Skovde, Sweden Sahlgrenska Univ Hosp, Dept Obstet & Gynaecol, Gothenburg, Sweden Cent Hosp Boras, Dept Obstet & Gynaecol, Boras, Sweden Linkoping Univ Hosp, Dept Obstet & Gynaecol, Linkoping, Sweden Cent Hosp Jonkoping, Dept Obstet & Gynaecol, Jonkoping, Sweden Univ Lund Hosp, Dept Obstet & Gynaecol, Lund, Sweden Haukeland Hosp, Dept Obstet & Gynaecol, N-5021 Bergen, Norway Ulleval Hosp, Dept Obstet & Gynaecol, Oslo, Norway Aker Hosp, Dept Obstet & Gynaecol, Oslo, Norway.
Cent Hosp Skovde, Dept Obstet & Gynaecol, S-54185 Skovde, Sweden Sahlgrenska Univ Hosp, Dept Obstet & Gynaecol, Gothenburg, Sweden Cent Hosp Boras, Dept Obstet & Gynaecol, Boras, Sweden Linkoping Univ Hosp, Dept Obstet & Gynaecol, Linkoping, Sweden Cent Hosp Jonkoping, Dept Obstet & Gynaecol, Jonkoping, Sweden Univ Lund Hosp, Dept Obstet & Gynaecol, Lund, Sweden Haukeland Hosp, Dept Obstet & Gynaecol, N-5021 Bergen, Norway Ulleval Hosp, Dept Obstet & Gynaecol, Oslo, Norway Aker Hosp, Dept Obstet & Gynaecol, Oslo, Norway.
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2000 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, Vol. 79, no 5, 390-396 p.Article in journal (Refereed) Published
Abstract [en]

Background. Bacterial vaginosis (BV) and intermediate flora is known risk-factor for post-operative infection after surgical termination of pregnancy. Vaginal application of 2% clindamycin cream is an efficacious treatment for BV, but it is not known whether preoperative administration of clindamycin cream might reduce the signs of post-abortion infection after surgical termination of pregnancy. Aim. To evaluate whether preoperative treatment with clindamycin cream might reduce the signs of post-abortion infection after legal abortion. Design. Prospective, double-blinded, placebo-controlled, multicenter study. Material and methods. Consecutive women attending for surgical termination prior to 11 + 4 gestational weeks were approached. We randomized participants to preoperative vaginal treatment with 2% clindamycin cream or placebo cream in a double-blinded fashion. At all visits vaginal smears were air dried on microscopy slides to be stored. The rate of postoperative pelvic infection according to our definition was the main outcome variable, the cure rates of BV and of intermediate flora were secondary outcome variables. Results. Of 1655 enrolled women, 1102 were evaluable for analyses. Fifty-eight women developed signs of post-abortion infection. Preoperative treatment with clindamycin cream significantly (RR: 4.2, 95% C.I. 1.2-15.9) reduced the risk of post-abortion infection among women with abnormal vaginal Bora (BV and intermediate flora). Treatment with clindamycin cream in women with normal lactobacilli flora did not demonstrate any difference compared to the non-treatment group. Conclusion. Preoperative treatment for at least three days with clindamycin cream significantly reduced the risk for developing signs of post-abortion infection only among women with preoperative abnormal vaginal flora (BV and intermediate flora).

Place, publisher, year, edition, pages
2000. Vol. 79, no 5, 390-396 p.
Keyword [en]
bacterial vaginosis, infection, legal abortion, treatment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-49748OAI: oai:DiVA.org:liu-49748DiVA: diva2:270644
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-14

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Larsson, Per-GöranFåhraeus, Lars

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Larsson, Per-GöranFåhraeus, Lars
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Faculty of Health SciencesGender and medicine Obstetrics and gynecology Department of Gynecology and Obstetrics in Linköping
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Acta Obstetricia et Gynecologica Scandinavica
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