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Analysis of progression and survival after 10 years of a randomized prospective study comparing mitomycin-C and bacillus Calmette-Guérin in patients with high-risk bladder cancer
Gårdmark, T., Department of Urology, Surgical Sciences, Uppsala, Sweden.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Urology in Östergötland.
Department of Urology, Surgical Sciences, Oslo, Norway.
Wijkström, H., Department of Urology, Surgical Sciences, Stockholm, Sweden.
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2007 (English)In: BJU International, ISSN 1464-4096, Vol. 99, no 4, 817-820 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To report the 10-year follow-up of a study randomizing between instillations of bacillus Calmette-Guérin (BCG) and mitomycin-C (MMC) for treating high-risk and not muscle-invasive urinary bladder cancer to assess progression, the need for more aggressive treatment and survival (cancer-specific and overall), as many of the published studies comparing different treatments for disease that is not muscle-invasive have a short follow-up. PATIENTS AND METHODS: Between 1987 and 1992, 261 patients were included, they had frequently recurring Ta/T1G1-G2, T1G3 or primary Tis-dysplasia. The patients were randomized to treatment with either 40 mg of MMC or 120 mg of BCG (Danish strain 1331) given weekly for 6 weeks, then monthly up to a year and finally every third month for a further year. The 250 evaluable patients were followed using hospital files and national registers on causes of death. RESULTS: The median follow-up for survivors was 123 months. The disease progressed in 58 (23%) of the patients, 34 in the MMC group and 24 in the BCG group (P = 0.26). Of the 140 patients who died, 68 were in the BCG and 72 in the MMC group (log-rank P = 0.98), most (95, 68%) died from other causes. CONCLUSION: Based on the follow-up of the present patients it cannot be concluded that the drugs originally administered, MMC or BCG, differed in their effect on progression, need for subsequent treatment or survival. © 2007 The Authors.

Place, publisher, year, edition, pages
2007. Vol. 99, no 4, 817-820 p.
Keyword [en]
BCG, Bladder cancer, Intravesical, Long-term, Mitomycin-C
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-49947DOI: 10.1111/j.1464-410X.2006.06706.xOAI: diva2:270843
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Jahnson, Staffan
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Faculty of Health SciencesSurgery Department of Urology in Östergötland
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