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Extra-cellular matrix proteins induce re-distribution of a-actinin-1 and a-actinin-4 in A431 cells
Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation.
Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation.
Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation.
Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation.
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2007 (English)In: Cell Biology International, ISSN 1065-6995, E-ISSN 1095-8355, Vol. 31, no 4 SPEC. ISS., 360-365 p.Article in journal (Refereed) Published
Abstract [en]

Alpha-actinins are actin-binding proteins of non-muscle cells, which can participate in the regulation of transcription factor activity. We describe the distribution of a-actinin-1 and -4 depending on different actin cytoskeleton formed as a result of cell adhesion to extracellular matrix proteins, such as fibronectin and laminin 2/4. Immunofluorescent studies show a difference in the distribution of a-actinin and -4. Both isoforms localise along stress-fibres, but a-actinin-1 localises in the perinuclear region more abundantly than a-actinin-4. Western blot analysis demonstrated existence of truncated forms of both isoforms. Truncated a-actinin-1 appears in cells spread on fibronectin or laminin. Cell spreading also correlated with more tight association of a-actinin-4 with chromatin. Basing on our previous finding of an interaction of a-actinin-4 with p65 subunit of the NF-?B, we checked the possible influence of immobilised ligands on its redistribution in nuclear complexes containing p65. a-Actinin-4 seems to be present in some but not all nuclear complexes containing p65. Immobilised ligands may affect the interaction of a-actinin-4/p65 complexes with chromatin. The data suggest that adhesion to extra-cellular matrix may interfere in cellular reactions mediated by a-actinin-1 and -4. © 2007 International Federation for Cell Biology.

Place, publisher, year, edition, pages
2007. Vol. 31, no 4 SPEC. ISS., 360-365 p.
Keyword [en]
a-Actinin-1, a-Actinin-4, Actin cytoskeleton, Extra-cellular matrix, NF-?B
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-49950DOI: 10.1016/j.cellbi.2007.01.021OAI: oai:DiVA.org:liu-49950DiVA: diva2:270846
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Magnusson, Karl-Eric

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