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Inflammatory response to titanium surfaces with fibrinogen and catalase coatings: An in vitro study
Göransson, A., Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden, Department of Prosthetic Dentistry/Dental Material Science, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden, Department of Biomaterial Science, Department of Prosthetic Dentistry/Dental Material Science, Göteborg University, SE 405 30 Göteborg, Sweden.
Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden.
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Applied Physics .
Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden, Department of Prosthetic Dentistry/Dental Material Science, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
2007 (English)In: Journal of Biomedical Materials Research - Part A, ISSN 1549-3296, Vol. 80, no 3, 693-699 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to evaluate the possibility to modulate the early inflammatory response in vitro by coating titanium surfaces with candidate proinflammatory (fibrinogen coated turned titanium "Fib") and antiinflammatory proteins (catalase on top of fibrinogen coated turned titanium "Cat"). Additionally, turned titanium surfaces (Ti) were used as controls. The discs were incubated with human mononuclear cells. Adhered cells were investigated with respect to number, viability, differentiation (acute marker 27E10 vs. chronic marker RM3/1), and cytokine production (TNF-a and IL-10), after 24 and 72 h. The results indicated that it is possible to modulate the inflammatory response with protein coatings. However, the strongest inflammatory response, indicated by increased number of adhered cells and release of pro and antiinflammatory mediators, was induced by Cat. Furthermore, the cytokine production on this surface was not sensitive to LPS stimulation. Differentiation measured as the expression of the chronic cell surface marker, dominated after 72 h for all surface modifications and Cat displayed an increased number compared to the others. A decrease in the total number of adhered cells and amounts of TNF-a were observed on all surfaces over time. The cell viability was, in general, high for all tested surfaces. In conclusion, the study proved it possible to influence the early inflammatory response in vitro by immobilizing protein coatings to titanium surfaces. However, the catalase surface demonstrated the strongest inflammatory response, and the possibility to selectively use the potent antiinflammatory capacity of catalase needs to be further evaluated. © 2006 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
2007. Vol. 80, no 3, 693-699 p.
Keyword [en]
Coating, Fibrinogen, In vitro, Inflammatory, Titanium
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-49991DOI: 10.1002/jbm.a.30973OAI: oai:DiVA.org:liu-49991DiVA: diva2:270887
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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