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Autophagy, organelles and ageing
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Geriatric .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Pharmacology .
2007 (English)In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 211, no 2, 134-143 p.Article, review/survey (Refereed) Published
Abstract [en]

As a result of insufficient digestion of oxidatively damaged macromolecules and organelles by autophagy and other degradative systems, long-lived postmitotic cells, such as cardiac myocytes, neurons and retinal pigment epithelial cells, progressively accumulate biological 'garbage' ('waste' materials). The latter include lipofuscin (a non-degradable intralysosomal polymeric substance), defective mitochondria and other organelles, and aberrant proteins, often forming aggregates (aggresomes). An interaction between senescent lipofuscin-loaded lysosomes and mitochondria seems to play a pivotal role in the progress of cellular ageing. Lipofuscin deposition hampers autophagic mitochondrial turnover, promoting the accumulation of senescent mitochondria, which are deficient in ATP production but produce increased amounts of reactive oxygen species. Increased oxidative stress, in turn, further enhances damage to both mitochondria and lysosomes, thus diminishing adaptability, triggering mitochondrial and lysosomal pro-apoptotic pathways, and culminating in cell death. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Place, publisher, year, edition, pages
2007. Vol. 211, no 2, 134-143 p.
Keyword [en]
Ageing, Apoptosis, Autophagy, Lipofuscin, Lysosomes, Mitochondria, Oxidative stress, Reactive oxygen species
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-50022DOI: 10.1002/path.2094OAI: oai:DiVA.org:liu-50022DiVA: diva2:270918
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Terman, AlexeiGustafsson, BertilBrunk, Ulf

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