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Effects of astaxanthin supplementation on lipid peroxidation
Research Institute of Public Health, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland.
Research Institute of Public Health, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland, Department of Public Health and Clinical Nutrition, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland.
Nyyssönen, K., Research Institute of Public Health, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland, Research Institute of Public Health, University of Kuopio, P.O. Box 1627, FI-70210 Kuopio, Finland.
Oy Jurilab Ltd., Microkatu 1, FI-70210 Kuopio, Finland.
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2007 (English)In: International Journal for Vitamin and Nutrition Research, ISSN 0300-9831, Vol. 77, no 1Article in journal (Refereed) Published
Abstract [en]

Astaxanthin, the main carotenoid pigment in aquatic animals, has greater antioxidant activity in vitro (protecting against lipid peroxidation) and a more polar configuration than other carotenoids. We investigated the effect of three-month astaxanthin supplementation on lipid peroxidation in healthy non-smoking Finnish men, aged 19-33 years by using a randomized double-blind study design. Also absorption of astaxanthin from capsules into bloodstream and its safety were evaluated. The intervention group received two 4-mg astaxanthin (Astaxin®) capsules daily, and the control group two identical-looking placebo capsules. Astaxanthin supplementation elevated plasma astaxanthin levels to 0.032 µmol/L (p < 0.001 for the change compared with the placebo group). We observed that levels of plasma 12- and 15-hydroxy fatty acids were reduced statistically significantly in the astaxanthin group (p = 0.048 and p = 0.047 respectively) during supplementation, but not in the placebo group and the change of 15-hydroxy fatty acid was almost significantly greater (p = 0.056) in the astaxanthin group, as compared with the placebo group. The present study suggests that intestinal absorption of astaxanthin delivered as capsules is adequate, and well tolerated. Supplementation with astaxanthin may decrease in vivo oxidation of fatty acids in healthy men. © Hogrefe & Huber Publishers.

Place, publisher, year, edition, pages
2007. Vol. 77, no 1
Keyword [en]
Absorption, Astaxanthin, C18 hydroxy fatty acids, Free F2 isoprostanes, Lipid peroxidation, Safety
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-50029DOI: 10.1024/0300-9831.77.1.3OAI: oai:DiVA.org:liu-50029DiVA: diva2:270925
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-06

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Olsson, Anders G.

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Internal MedicineFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology
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