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Perturbations to uncover gene networks
Linköping University, Department of Physics, Chemistry and Biology, Computational Biology. Linköping University, The Institute of Technology. Unit of Computational Medicine, Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden and The Computational Medicine Group, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
Unit of Computational Medicine, Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden and The Computational Medicine Group, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
2007 (English)In: Trends in Genetics, ISSN 0168-9525, E-ISSN 1362-4555, Vol. 23, no 1, 34-41 p.Article, review/survey (Refereed) Published
Abstract [en]

After the major achievements of the DNA sequencing projects, an equally important challenge now is to uncover the functional relationships among genes (i.e. gene networks). It has become increasingly clear that computational algorithms are crucial for extracting meaningful information from the massive amount of data generated by high-throughput genome-wide technologies. Here, we summarise how systems identification algorithms, originating from physics and control theory, have been adapted for use in biology. We also explain how experimental perturbations combined with genome-wide measurements are being used to uncover gene networks. Perturbation techniques could pave the way for identifying gene networks in more complex settings such as multifactorial diseases and for improving the efficacy of drug evaluation. © 2006 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2007. Vol. 23, no 1, 34-41 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-50034DOI: 10.1016/j.tig.2006.11.003ISI: 000243709500010OAI: oai:DiVA.org:liu-50034DiVA: diva2:270930
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12Bibliographically approved

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Tegnér, Jesper

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