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Systems biology of innate immunity
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Computational Biology .
Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Computational Biology .
University of Western Cape, SANBI, Bellville, 7535, South Africa.
Björkegren, J., Unit of Computational Medicine, King Gustaf V Research Institute, Department of Medicine, SE-171 76 Stockholm, Sweden.
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2006 (English)In: Cellular Immunology, ISSN 0008-8749, Vol. 244, no 2, 105-109 p.Article in journal (Refereed) Published
Abstract [en]

Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes. These endeavors, collectively referred to as systems biology establish a paradigm by which to systematically interrogate, model, and iteratively refine our knowledge of the regulatory events within a cell. Here, we present a new systems approach, integrating DNA and transcript expression information, specifically designed to identify transcriptional networks governing the macrophage immune response to lipopolysaccharide (LPS). Using this approach, we are not only able to infer a global macrophage transcriptional network, but also time-specific sub-networks that are dynamically active across the LPS response. We believe that our system biological approach could be useful for identifying other complex networks mediating immunological responses. © 2007 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 244, no 2, 105-109 p.
Keyword [en]
Dynamics, Genome, Innate immunity, Macrophages, Networks, Protein-protein interactions, Regulatory circuits, Systems biology, Transcriptional regulation
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-50063DOI: 10.1016/j.cellimm.2007.01.010OAI: oai:DiVA.org:liu-50063DiVA: diva2:270959
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Tegnér, JesperNilsson, Roland

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