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Contrast enhancement of manganese-hydroxypropyl-tetraacetic acid, an MR contrast agent with potential for detecting differences in myocardial blood flow
MR Unit, Department of Radiology, Uppsala University Hospital, Uppsala, Sweden, Magnetkameran Ing. 24, Dept. of Radiology, Uppsala University Hospital, 751 85 Uppsala, Sweden.
MR Unit, Department of Radiology, Uppsala University Hospital, Uppsala, Sweden.
MR Unit, Department of Radiology, Uppsala University Hospital, Uppsala, Sweden.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences.
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2006 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 24, no 4, 858-863 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To determine whether the contrast agent Mn-HPTA has potential for detecting differences in myocardial blood flow. Materials and Methods: R1 in the myocardium was calculated from MR signal intensity measurements in 18 pigs after intravenous injection of 5, 15, or 25 µmol MnHPTA/kg body weight. Measurements were made in each animal after administration at rest and during dobutamine-induced stress. Results: A difference of approximately 0.1 sec -1 in the R1 increase between rest and stress still remained 31 minutes after administration of 25 µmol MnHPTA/kg body weight. When two consecutive MnHPTA injections were performed, the second injection induced a lower R1 increase than the corresponding first injection. Conclusion: MnHPTA at a dose of 25µmol/kg body weight (b.w.) has the potential to detect perfusion differences in myocardium. When two consecutive injections of MnHPTA were administered, the R1 change after the second injection was affected by the earlier administration. Therefore, a protocol including more than one administration is not ideal for this contrast agent. © 2006 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2006. Vol. 24, no 4, 858-863 p.
Keyword [en]
Animal study, Contrast agent, Magnetic resonance, Manganese, Myocardium
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-50113DOI: 10.1002/jmri.20718OAI: oai:DiVA.org:liu-50113DiVA: diva2:271009
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Karlsson, Jan Olof

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