2006 (English)In: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, ISSN 1521-6543, Vol. 58, no 9, 531-539 p.Article, review/survey (Refereed) Published
The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death. It is now realized that lysosomes instead are quite vulnerable, although in a heterogeneous way. Their exposure to a number of events, such as oxidative stress, lysosomotropic detergents and aldhydes, as well as overexpression of the p53 protein, causes time-and-dose-dependent lysosomal rupture that is followed by apoptosis or necrosis. Partial lysosomal rupture has often been found to be an early upstream event in apoptosis, while necrosis results from fulminant lysosomal rupture. Consequently, factors influencing the stability of lysosomes, for instance their content of labile and redox-active iron, seem to be essential for the survival of cells. © 2006 IUBMB.
Place, publisher, year, edition, pages
2006. Vol. 58, no 9, 531-539 p.
Cell death, Lysosomes, Oxidative stress, Redox-active iron
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-50149DOI: 10.1080/15216540600904885OAI: oai:DiVA.org:liu-50149DiVA: diva2:271045