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Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption. A prospective randomised double-blinded study
Department of Orthopedics, Lund University Hospital, SE-221 85 Lund, Sweden.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2006 (English)In: Journal of Bone and Joint Surgery, ISSN 0301-620X, Vol. 88, no 8, 993-996 p.Article in journal (Refereed) Published
Abstract [en]

During revision total hip replacement using morcellised compacted bone allograft, 16 patients were randomised to receive a graft which had been rinsed in either an ibandronate solution or in saline. Patients were assessed by dual energy x-ray absorptiometry after operation and at 3, 6, 12 and 24 months. A region of interest between the tip of the femoral stem and the distal plastic plug was chosen to measure the changes in bone density over time. The study was double-blinded. In all the control patients the bone density decreased during the first three months and then remained constant at this lower level. A large proportion of the mass of the bone graft was lost. In contrast, all patients with grafts treated with bisphosphonate showed a slight increase in bone density. The difference between the groups was highly significant at all points in time. We conclude that rinsing the graft in a bisphosphonate solution prevents its resorption and may therefore reduce the risk of mechanical failure. The treatment is simple, inexpensive, and appears virtually free of risk. ©2006 British Editorial Society of Bone and Joint Surgery.

Place, publisher, year, edition, pages
2006. Vol. 88, no 8, 993-996 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-50175DOI: 10.1302/0301-620X.88B8.17457OAI: diva2:271071
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-11

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports Medicine Department of Orthopaedics Linköping
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