Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children
2006 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 61, no 7, 855-859 p.Article in journal (Refereed) Published
Background: A 3-year course of specific immunotherapy (SIT) in children with hay fever to grass and/or birch pollen significantly reduced the risk of developing asthma. To investigate the long-term preventive effect, we performed a follow up – 2 years after termination of immunotherapy.
Methods: A total of 183 children, aged 6–14 years with grass and/or birch pollen allergy could be investigated 2 years after discontinuation of SIT or no treatment. Conjunctival provocation tests (CPTs) and methacholine bronchial provocation tests were carried out during the season and winter after 5 years. The development of asthma was assessed by clinical evaluation.
Results: The significant improvement in hay fever and CPT results observed after 3 years of SIT persisted at the 5-year follow-up. No difference in bronchial responsiveness to methacholine was found after 5 years because of spontaneous improvement during the follow-up period in the control patients. The immunotherapy-treated children had significantly less asthma after 5 years as evaluated by clinical symptoms [odds ratio 2.68 (1.3–5.7)] in favor of SIT for prevention of development of asthma and significantly less patients reported an increase in asthma scores (P < 0.01).
Conclusion: Immunotherapy for 3 years with standardized allergen extracts of grass and/or birch shows long-term clinical effect and preventive effect on development of asthma in children with seasonal rhinoconjunctivitis.
Place, publisher, year, edition, pages
2006. Vol. 61, no 7, 855-859 p.
Asthma, Bronchial hyperresponsiveness, Long-term effect, Prevention, Rhinitis, Specific immunotherapy
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-50180DOI: 10.1111/j.1398-9995.2006.01068.xOAI: oai:DiVA.org:liu-50180DiVA: diva2:271076