Synthesis of the Trypanosoma cruzi LPPG heptasaccharyl myo-inositol
2006 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 128, no 10, 3414-3419 p.Article in journal (Refereed) Published
Synthesis of the heptasaccharyl myo-inositol found in Trypanosoma cruzi lipopeptidophosphoglycan was accomplished using a convergent assembly of three building blocks. The target compound is the first complete 2-aminoethyl phosphonic acid substituted glycan related to the glycosylphosphatidylinositol anchor family to be synthesized. The order of assembly enables synthesis of phosphoinositol oligosaccharides related to other glycosylinositolphospholipids in Tr. cruzi, the protozoan parasite causing Chagas' disease, which is endemic in South America.
Place, publisher, year, edition, pages
2006. Vol. 128, no 10, 3414-3419 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-50263DOI: 10.1021/ja057339bOAI: oai:DiVA.org:liu-50263DiVA: diva2:271159