liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Long-term cardiac outcomes in renal transplant recipients receiving fluvastatin: The ALERT extension study
Rikshospitalet, Oslo, Norway.
Fellström, B., University Hospital, Uppsala, Sweden.
University Health Network, Toronto, Canada.
Sahlgrenska Academy, Göteborg, Sweden.
Show others and affiliations
2005 (English)In: American Journal of Transplantation, ISSN 1600-6135, E-ISSN 1600-6143, Vol. 5, no 12, 2929-2936 p.Article in journal (Refereed) Published
Abstract [en]

Renal transplant recipients (RTR) have an increased risk of premature cardiovascular disease. The ALERT study is the first trial to evaluate the effect of statin therapy on cardiac outcomes following renal transplantation. Patients initially randomized to fluvastatin or placebo in the 5-6 year ALERT study were offered open-label fluvastatin XL 80 mg/day in a 2-year extension to the original study. The primary endpoint was time to first major adverse cardiac event (MACE). Of 1787 patients who completed ALERT, 1652 (92%) were followed in the extension. Mean total follow-up was 6.7 years. Mean LDL-cholesterol was 98 mg/dL (2.5 mmol/L) at last follow-up compared to a pre-study level of 159 mg/dL (4.1 mmol/L). Patients randomized to fluvastatin had a reduced risk of MACE (hazards ratio [HR] 0.79, 95% CI 0.63-0.99, p = 0.036), and a 29% reduction in cardiac death or definite non-fatal MI (HR 0.71, 95% CI 0.55-0.93, p = 0.014). Total mortality and graft loss did not differ significantly between groups. Fluvastatin produces a safe and effective reduction in LDL-cholesterol associated with reduced risk of MACE in RTR. The lipid-lowering and cardiovascular benefits of fluvastatin are comparable to those of statins in other patient groups, and support use of fluvastatin in RTR. Copyright © Blackwell Munksgaard 2005.

Place, publisher, year, edition, pages
2005. Vol. 5, no 12, 2929-2936 p.
Keyword [en]
ALERT, Cardiovascular disease, Fluvastatin, Major cardiac adverse event, Renal transplantation, Risk
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-50345DOI: 10.1111/j.1600-6143.2005.01105.xOAI: diva2:271241
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2012-01-07

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Olsson, Anders G.
By organisation
Internal MedicineFaculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHL
In the same journal
American Journal of Transplantation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link