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The B cells are back!
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Rheumatology . Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.ORCID iD: 0000-0002-0153-9249
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Rheumatology . Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Rheumatology . Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.
2005 (English)In: Drug Discovery Today: Disease Mechanisms, ISSN 1740-6765, Vol. 2, no 3, 351-357 p.Article, review/survey (Refereed) Published
Abstract [en]

New interest has emerged regarding the central roles of B cells in physiological immunoregulation and immunopathogenesis of rheumatoid arthritis (RA), a condition traditionally viewed as T-cell mediated. Thus, B cells, autoantibodies, immune complexes, complement and their cellular receptors are experiencing renewed interest concerning their roles in the initiation and propagation of arthritis. The discovery of citrullinated proteins as targets of autoimmune response in RA has implications regarding aetiopathogenesis, prediction of future disease, diagnosis of recent onset and established arthritis and prediction of disease course and disease outcome. Antibody-based therapies against cytokines, cytokine receptors and B cells contribute to the important advances in antirheumatic therapy. © 2005 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 2, no 3, 351-357 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-50373DOI: 10.1016/j.ddmec.2005.08.007OAI: oai:DiVA.org:liu-50373DiVA: diva2:271269
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2015-08-31

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Skogh, ThomasKastbom, AlfSjöwall, Christoffer

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