Measuring the size of the extracellular fluid space using bromide, iohexol, and sodium dilution
2005 (English)In: Anesthesia and Analgesia, ISSN 0003-2999, E-ISSN 1526-7598, Vol. 101, no 6, 1770-1777 p.Article in journal (Refereed) Published
There is a need to find methods to assess the size of the extracellular fluid (ECF) volume without involving radioactive tracers. For this purpose, we applied 3 methods for measuring the ECF volume in 10 male volunteers (mean age, 34 yr). Steady-state plasma bromide concentration (control) was compared to the results of kinetic analysis of plasma iohexol and to kinetic analysis of the dilution of serum sodium after IV infusion of 1 L of isotonic mannitol. The volume of distribution of these tracers was used to indicate the ECF volume. The results disclosed statistically significant correlations between the results of all 3 methods, although the average sodium dilution showed 0.7 L lower values than iohexol and 1.4 L lower than bromide. All three methods correlated significantly with body weight. The percentage of the body weight indicated by the methods was 18.3% (3.1%) for sodium, 19.6% (1.0%) for iohexol, and 20.5% (1.1%) for bromide. We conclude that sodium dilution may be performed at bedside but iohexol and bromide showed less intersubject variability. Iohexol simultaneously measures the glomerular filtration rate and should be a viable clinical option if the hospital performs routine assessments of kidney function using this tracer. ©2005 by the International Anesthesia Research Society.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2005. Vol. 101, no 6, 1770-1777 p.
National CategoryAnesthesiology and Intensive Care
IdentifiersURN: urn:nbn:se:liu:diva-50378DOI: 10.1213/01.ANE.0000184043.91673.7EISI: 000233512400038PubMedID: 16301257ScopusID: 2-s2.0-28344440939OAI: oai:DiVA.org:liu-50378DiVA: diva2:271274
28th Congress of the Scandinavian-Society-of-Anaesthesiology-and-Intensive-Care-Medicine, Reykjavik, Iceland, June 29-July 03, 2005