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Measuring the size of the extracellular fluid space using bromide, iohexol, and sodium dilution
Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Intensive Care UHL.
Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences.
Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden.
2005 (English)In: Anesthesia and Analgesia, ISSN 0003-2999, E-ISSN 1526-7598, Vol. 101, no 6, 1770-1777 p.Article in journal (Refereed) Published
Abstract [en]

There is a need to find methods to assess the size of the extracellular fluid (ECF) volume without involving radioactive tracers. For this purpose, we applied 3 methods for measuring the ECF volume in 10 male volunteers (mean age, 34 yr). Steady-state plasma bromide concentration (control) was compared to the results of kinetic analysis of plasma iohexol and to kinetic analysis of the dilution of serum sodium after IV infusion of 1 L of isotonic mannitol. The volume of distribution of these tracers was used to indicate the ECF volume. The results disclosed statistically significant correlations between the results of all 3 methods, although the average sodium dilution showed 0.7 L lower values than iohexol and 1.4 L lower than bromide. All three methods correlated significantly with body weight. The percentage of the body weight indicated by the methods was 18.3% (3.1%) for sodium, 19.6% (1.0%) for iohexol, and 20.5% (1.1%) for bromide. We conclude that sodium dilution may be performed at bedside but iohexol and bromide showed less intersubject variability. Iohexol simultaneously measures the glomerular filtration rate and should be a viable clinical option if the hospital performs routine assessments of kidney function using this tracer. ©2005 by the International Anesthesia Research Society.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2005. Vol. 101, no 6, 1770-1777 p.
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:liu:diva-50378DOI: 10.1213/01.ANE.0000184043.91673.7EISI: 000233512400038PubMedID: 16301257ScopusID: 2-s2.0-28344440939OAI: diva2:271274
28th Congress of the Scandinavian-Society-of-Anaesthesiology-and-Intensive-Care-Medicine, Reykjavik, Iceland, June 29-July 03, 2005
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2015-06-09Bibliographically approved

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