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Failure of the PAXgene™ Blood RNA System to maintain mRNA stability in whole blood
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Hematology .
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2005 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 43, no 11, 1190-1192 p.Article in journal (Refereed) Published
Abstract [en]

In multicentre studies of malignant and inflammatory diseases, whole blood, cell or tissue samples are often collected for analyses of gene expression to predict or monitor treatment effects. For correct analysis, sample stability during handling and transport is crucial. In developing the logistics for multicentre studies in malignant melanoma and inflammatory bowel disease, we found poor stability of a number of transcripts using the PAXgene™ Blood RNA System, which was advertised to maintain RNA stability for several days at room temperature. The results indicate that general statements on sample stability are not reliable and have to be verified for the specific transcripts of interest. © 2005 by Walter de Gruyter. Berlin.

Place, publisher, year, edition, pages
2005. Vol. 43, no 11, 1190-1192 p.
Keyword [en]
PAXgene™ blood RNA system, Preanalytics, Transcript stability
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-50386DOI: 10.1515/CCLM.2005.206OAI: oai:DiVA.org:liu-50386DiVA: diva2:271282
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12

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Kågedal, BertilLindqvist, MariaFarnebäck, MalinLenner, LiselottePeterson, Curt

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Kågedal, BertilLindqvist, MariaFarnebäck, MalinLenner, LiselottePeterson, Curt
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Faculty of Health SciencesClinical ChemistryDepartment of Molecular and Clinical MedicineExperimental Hematology Clinical Pharmacology Department of Oncology UHL
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